Enzymatic and non-enzymatic antioxidant activity of Pergularia tomentosa against carbon tetra chloride induced hepatic damage in Wistar albino rats

  • Vinoth Kumar Department of Microbiology, Southwest Medical University, Luzhou city, 646000, PR China
  • Malliga Elangovan Department of Biochemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India
  • Raja Sekar Srinivasan Department of Microbiology, Sribharathi Arts and Science College, Kaikkurichy, Pudukottai, Tamil Nadu, India


Many oxidative stress related disease are due to accumulation of free radicals in the body which causes cell injury. In this study, the enzymatic antioxidants (Superoxide dismutase, Catalase, Glutathione-s-transferase, Glutathione peroxidase, Ascorbate oxidase and Polyphenoloxidase) and non-enzymatic antioxidants (Total reduced glutathione and Vitamin C) activities were determined using Carbon tetrachloride (CCl4) rat liver as experimental model. The ethanol and chloroform extract showed noticeable increases in enzymatic antioxidant and non- enzymatic antioxidant and thus capability to scavenge the free radicals and protect against oxidative stress causing diseases. Thus, the present study indicates that the plant may be clinically valuable agent in the prevention of hepatic failure caused by CCl4 intoxication. 


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